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Risk Factors Associated with Carpal Tunnel Syndrome

Numerous factors have been linked to carpal tunnel syndrome, although they may not directly induce the condition. It is important to remember, though, that these factors can heighten the risk of irritation or damage to the median nerve. 

Anatomic Factors

Wrist fractures, dislocations, or arthritis that affects the bones in your wrist can change the space within the carpal tunnel, thereby exerting pressure on the median nerve.


Carpal Tunnel Syndrome is more widespread among women. This is likely because women have a smaller carpal tunnel area than men.  

Nerve-Damaging Conditions

Chronic illnesses like diabetes elevate the risk of damaging nerves, including damage to the median nerve.

Inflammatory Conditions

Conditions with an inflammatory component, such as rheumatoid arthritis, can impact the lining of tendons around the wrist and exert pressure on the median nerve. 


A few studies have shown a link between the use of anastrozole (Arimidex) and the occurrence of carpal tunnel syndrome. 


Obesity is a commonly recognized risk factor for CTS. 

Body Fluid Changes

Fluid retention can elevate the pressure within the carpal tunnel and irritate the median nerve. Body fluid changes are common in pregnancy and menopause. 

Other Medical Conditions

Conditions like menopause, thyroid disorders, kidney failure, and lymphedema may increase the likelihood of carpal tunnel syndrome.

Workplace Factors

Finally, workplace factors such as working with vibrating tools or in assembly lines involving prolonged or repetitive wrist flexing can exert harmful pressure on the median nerve, especially in cold environments.

Some studies have explored the relationship between computer use and carpal tunnel syndrome, with limited evidence suggesting that mouse use, rather than keyboard use, may be a potential issue.

There is no sufficient consistent evidence, however, to firmly establish extensive computer use as a significant risk factor for carpal tunnel syndrome, though it may contribute to a different form of hand pain.